Humans have prevailed in the battle with most other species, including bacteria and viruses. The target of medical treatment has changed to systemic diseases that occur without provocation, such as cancers and degenerative diseases.
As an ophthalmologist, when I examine patients with incurable diseases, I always hope to relieve their suffering, but often have a sense of helplessness. One day, Dr. Yoshimura, a professor in the department of ophthalmology at Kyoto University, challenged me to start a bio-venture company. I founded KDDD (Kyoto Drug Discovery & Development Co., Ltd.), which remains affiliated and collaborates with Kyoto University.
KDDD develops KUSs (Kyoto University Substances). The first inventor of a product is Dr. Kakizuka, professor in the graduate school of biostudies at Kyoto University; the second inventor is Dr. Ikeda, associate professor at Kyoto University Hospital. KUSs are novel compounds that improve ATP consumption by inhibiting the ATPase of VCP and protect cells from a lot of kind of damages, such as degeneration and ischemic damage. In animal models, KUSs have neuroprotective effects for chronic degenerative diseases such as retinitis pigmentosa and glaucoma. Our mission is to develop KUSs for treatment of patients with incurable eye disease. As KUSs have a unique mechanism, they may also provide strong cell-protective effects in other diseases.
Our Mission
- strong passion to develop and make drugs available for incurable diseases
- strong social responsibility
- gratitude to society, academia, and the medical field
We promise a sincere commitment to global health.
Our mission is to supply effective drugs for current and future patients with incurable diseases.
Kunihiro Musashi


Corporate name

Kyoto Drug Discovery & Development Co., Ltd.


International Science Innovation Building, Kyoto University
36-1 Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501 JAPAN


#416, Med-Pharm Collaboration Building, Kyoto University
46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto 606-8501 JAPAN

Osaka Office

5-52-206 Fudegasaki-cho, Tennoji, Osaka, 543-0027, JAPAN

President & CEO

Kunihiro Musashi

Major Business Activities

Research and Development of Drug, Diagnostic Drug, Human Cell Therapy and Gene therapy Products, Medical Equipment, Medical Instruments, Reagent and Medical Supplies


May 15th. 2015

Account Closing Month



161.4 mi. yen(as of February 28th, 2018)

Our Bank

Bank of Tokyo-Mitsubishi UFJ, Toji Branch
Sumitomo Mitsui Banking Corporation, Kyoto Branch


February 28th, 2018

Total 142.8mil. Yen investments from two venture capitals

August 1st, 2017

Labo was established in a building in Kyoto University

September 27th, 2016

Headquarters moves into a building in Kyoto University

June 30th, 2016

Total 430mil. Yen investments from five venture capitals

June 17th, 2016

Capital reached 140mil. Yen (including capital reserve)

March 30th, 2016

License Agreement with Kyoto University

May 15th, 2015

Established (Capital 21mil. Yen)


KDDD aims to bring “Brightness” to patients with incurable diseases, now and in the future, by development of seeds discovered at Kyoto University. KDDD was conceived in the department of ophthalmology and graduate school of biostudies of Kyoto University in May 2015. KDDD, as a university-sponsored venture, will maintain a strong partnership with Kyoto University and promote development of our product.


Representative Director, CEO Head Administrative Officer  Kunihiro Musashi
Director Research Promotion Department
General Manager
Noriyuki Kuno
Director CMC Planning Department
General Manager
Masaki Okamoto
Director Business Development Department
General Manager
Sakae Muto
  Clinical Development Department
General Manager
Fumiki Hirata
  CMC Planning Department
Research Promotion Department
Yukiko Yamamoto
Outside Director  Kyoto University Innovation Capital Nobuhiro Yagi
Outside Company Auditor  Kazuyoshi Tsuda CPA and
certified tax accountant office
Kazuyoshi Tsuda
 Medical Advisor  Kyoto University
Professor Emeritus
Nagahisa Yoshimura
 Medical Advisor  Kyoto University Hospital
Associate Professor
Hanako Ohashi Ikeda
As of May 11th, 2018

About KUSs

KUSs, Kyoto University Substances, are valosin-containing protein (VCP) modulators. They ameliorated abnormally low ATP levels by inhibiting the ATPase of VCP, thereby protected cells from degeneration and death. Several reports were provided that KUSs have neuroprotective effects that protect retinal nerve fibers and retinal ganglion cells on animal models. The facts may contribute to deterioration restraint of glaucoma. Glaucoma is a leading cause of vision loss worldwide. Lowering intraocular pressure by drugs and/or surgery is the only evidence-based treatment of glaucoma. We believe that KUSs will be able to provide convenient novel therapeutics for neuroprotection in incurable eye diseases such as glaucoma. KUSs may also provide novel strategy for cell protection in other areas.